Question 1

How long does it take to lose weight on semaglutide?

Accepted Answer

The STEP-1 clinical trial ran for 68 weeks and showed an average body weight loss of 14.9% with semaglutide 2.4mg. Most patients begin noticing appetite suppression within the first 1 to 2 weeks. Meaningful weight loss typically becomes visible by weeks 4 to 8. Peak results accumulate over the full titration period of 16 to 20 weeks as doses increase. Individual results vary based on starting weight, adherence, diet, and activity level.

Question 2

How long does it take to lose weight on tirzepatide?

Accepted Answer

The SURMOUNT-1 clinical trial ran for 72 weeks and showed an average body weight loss of 22.5% with tirzepatide 15mg. Appetite changes typically begin within the first 1 to 2 weeks. Significant weight loss generally begins between weeks 4 and 8, with results building through the full titration schedule over approximately 20 to 24 weeks. Individual results vary.

Question 3

How much weight can you lose in 3 months on semaglutide?

Accepted Answer

Based on the STEP-1 trial weight loss curve, most patients lose approximately 5 to 8% of body weight in the first 12 weeks on semaglutide. At this stage doses are still titrating upward from the 0.25mg starting dose toward the 1mg range. Weight loss accelerates as doses increase over subsequent months. Individual results vary significantly.

Question 4

How much weight can you lose in 3 months on tirzepatide?

Accepted Answer

Based on the SURMOUNT-1 trial weight loss curve, most patients lose approximately 7 to 10% of body weight in the first 12 weeks on tirzepatide. Doses at this stage are titrating from 2.5mg through 7.5mg. Weight loss continues accelerating through the higher dose phases. Individual results vary significantly.

Question 5

Is the GLP-1 weight loss timeline calculator at Ondra Health free?

Accepted Answer

Yes. The GLP-1 weight loss timeline calculator at Ondra Health is completely free. Enter your current weight, goal weight, activity level, and medication choice — semaglutide or tirzepatide — to receive a week-by-week projection based on clinical trial data.

Question 6

What clinical trials is the GLP-1 timeline calculator based on?

Accepted Answer

The calculator is modeled on two trials: the STEP-1 trial (Wilding et al., NEJM 2021, PMID 33567185), which showed −14.9% average body weight loss with semaglutide 2.4mg over 68 weeks, and the SURMOUNT-1 trial (Jastreboff et al., NEJM 2022, PMID 35658024), which showed −22.5% average body weight loss with tirzepatide 15mg over 72 weeks.

How long to reach
your goal weight?

Based on real clinical trial data

How long to reachyour goal weight?

Based on real clinical trial data

How long to reach
your goal weight?